Research suggests that high levels of homocysteine in the blood is a contributory factor in heart disease, strokes and thrombosis amongst other diseases, and experts are hailing it a better predictor of potential health problems than cholesterol.
Says Patrick Holford Author and Founder of the Institute of Optimum Nutrition. 'Your homocysteine is your most vital health statistic - more important than your weight or blood. It literally tells you where you are on the scale of health and whether you are doing enough to keep yourself in tip-top condition'
The YORKTEST. HOMOCYSTEINE TEST allows you to easily check your levels of homocysteine using a unique plasma separator device, developed by YORK LABORATORIES research scientists.
A pinprick sample of blood is required. With the YORKTEST HOMOCYSTEINE TEST KIT, customers can take their own blood sample at home using the unique 'plasma separator' whereby a small amount of blood (approx. 50ul) is dropped onto a card and the membrane within the card then separates the plasma from the red blood cells automatically.
This blood sample is then sent back to the laboratory and tested using HPLC and the results reported back in approximately five days.
The final result is calculated using reference standard preparations. The specialised software computes the information to determine your 'H-Score' (homocysteine results).
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Description:
Homocysteine Hcy is a naturally occurring sulphur containing amino acid present in the blood and formed in the metabolism of methione. Plasma homocysteine is usually rapidly metabolised either via a vitamin B12 and folate dependent re-methylation pathway that regenerates methionine or a vitamin B6 dependent trans-sulphuration pathway that converts homocysteine to cysteine.
If these pathways are disrupted through dietary lack of folate, B12 or B6 or low levels of thyroid hormone, kidney disease, psoriasis, some medicines and ageing, Homocysteine Hcy accumulates in the cell and is then transported to the circulation where levels rise.
Elevated levels of Homocysteine Hcy cause cholesterol to change to something called oxidised low-density lipoprotein that promotes the build up of plaque on blood vessel walls, increasing the risk of heart attack, stroke and peripheral vascular disease (reduced blood flow to the legs and feet).
Evidence also suggests that excessive Homocysteine Hcy levels may have an effect on atherosclerosis by damaging the inner lining of arteries, interfering with healthy clotting factors by promoting blood clots and oxidation of low-density lipoproteins LDL.
Most people with a high Homocysteine Hcy levels don't get enough folic acid or B Vitamins in their diet. Other causes of high Homocysteine levels include low levels of thyroid hormone, kidney disease, psoriasis, some medicines and ageing.
Even moderately elevated Homocysteine Hcy levels are a strong risk factor for cardiovascular disease and many studies have also found an association between high Homocysteine Hcy with impaired cognitive performance and dementia development and progression.
In fact US HIS panellist Dr Allan Spreen believes that Homocysteine Hcy is a far more important indicator of arteriosclerosis risk than cholesterol and actively reducing Homocysteine Hcy levels can have a dramatic effect on heart health and circulation.
Just a 3umol/L drop in Homocysteine Hcy lessens the likelihood of heart attacks by 16%, strokes by 24% and deep vein thrombosis by 25% whilst a 5umol/L decrease in Homocysteine Hcy reduces the risk of death from all causes by 49%, death from cardiovascular disease by 50% and death from cancer by 26%.
Betaine Trimethyglycine is a naturally occurring nutrient derived from sugar beet that in synergy with other key nutrients helps to reduce potentially harmful levels of Homocysteine Hcy. Betaine Trimethyglycine functions at its best when in synergy with folic acid and Vitamins B12 and B6 to break down Homocysteine Hcy and reduce harmful levels in the bloodstream.
Homocysteine Hcy levels may be reduced with additional folates in the diet. But whilst additional doses of folate may work for some, folates may not be enough for cases of elevated Homocysteine Hcy
levels.
Recent studies at Wageningen University in the Netherlands have shown Betaine Trimethyglycine to be very effective at lowing levels of Homocysteine Hcy.
A study of 79 subjects grouped to receive 1.5gms and 6gms of Betaine Trimethyglycine Supplement and a placebo daily revealed that after just one day, the 1.5gm group had an average Homocysteine Hcy level 16% lower than the average placebo group, whilst in the 6gm group, the average reduction in Homocysteine Hcy levels was a full 35% when compared with the placebo group.
At the end of the study the results were even more impressive. Subjects in the 1.5gm group had an average Homocysteine Hcy level 23% lower than the placebo and in the 6gm group, the average level was 45% lower. The Wageningen researchers concluded that these significant drops in Homocysteine Hcy showed that a Betaine Trimethyglycine supplement or a Betaine Trimethyglycine rich diet might lower the risk of cardiovascular disease.
In addition to lowering Homocysteine Hcy levels, Betaine Trimethyglycine also assists in the processing of fats in the liver. And some studies have shown that Betaine Trimethyglycine may also help protect the liver from damage caused by chemicals and excess alcohol.
PLEASE NOTE: The homocysteine test is only available to UK customers.
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